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NanoFlowSizer
제품명: NanoFlowSizer
용도: Spatially Resolved Dynamic Light Scattering
메이커: InProcess-LSP
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소개

 

NanoFlowSizer    Unique Nanoparticle Characterization: Inline and Real-time Measurement In Flow

 


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How this analyzer is different


NanoFlowSizer (NFS) is a new non-invasive nanoparticle size analyzer developed by InProcess-LSP, the only one capable of carrying particle size and size distribution measurement for non-solid products inline, at the production flow, with no need to extract or treat a sample.

 

 

Results every 10 sec

 

With the NanoFlowSizer, nanoparticle sizing takes place within 10s, enabling continuous real-time in flow analysis.

 

 

Continuous, real-time nanoparticle size characterization

 

The NanoFlowSizer is a new innovative system for continuous, real-time 

nanoparticle size characterization of colloidal systems, nanosuspensions, 

nanoemulsions and other dispersed nanoproducts directly in manufacturing 

processes (inline) or in a laboratory setting (offline). 

 

 



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Process monitoring

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The result of this poor process control is uncertain product quality that leads to up to a 50% rejection rate in batch production for pharmaceutical companies. While also being able to carry out measurements offline, it is the NanoFlowSizer inline functionality that allows for complete control over the production process, an advantage highly demanded by pharmaceutical companies.

 

 

Save unnecessary costs

 

Having absolute control over the manufacturing conditions of nanoparticles leads to a reduction of batch rejection related to nanoparticle size measurements to 0. It simplifies the measurement process by eliminating the need for stopping production and the time-consuming and complicated sampling and sample treatment processes. As a result, the NanoFlowSizer can provide annual savings of as much as €3 million per produced drug. 

 

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Average particle size and size distributions every 10 seconds

 

 *  Inline Process Analytical Tool- Continuous size characterization of

    nanoparticles during processing

 *  Non-invasive measurement

 *  Real-time process feedback

 *  Measurement of highly turbid materials

 *  High-speed measurement

 *  Inline, online and offline operation

 *  For very small(<mL) to large sample volumes

 

 

 

 


“As an inline instrument, the NanoFlowSizer is a powerful non-invasive Process Analytical Tool allowing close monitoring of particle size characteristics in your process in either development laboratories, pilot plants or commercial operations, without the need of sampling.” 

 

 

 

 

 

 

NanoFlowSizer is made up of three main elements


    1. XsperGo software: Instrument control and particle size characteristics calculations

    2. Probe Unit: Interferometer + Optics

    3. The Base Unit: With the spectrometer and light source

 


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Flexible modular system providing different functionalities for various scales


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   1. Offline: At a location not being the production facility, i.e., laboratory (sampling required)

 


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   2. At-line: Static measurements carried out in proximity to the production process (sampling required) 

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   3. Online: Connected to the production flow by a sampling loop

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   4. Inline: In the production flow (continuous real-time measurements, no need for sampling and sample treatment)

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Nanoparticle Size Analysis Applications

 

 

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관련자료

 

NanoFlowSizer: the technology behind this new particle sizing instrument

 

 

Conventional DLS

Dynamic light scattering (DLS) is a well-accepted technology for measuring particle size and size distribution of nanoparticles in liquids. It is based on the measurement of fluctuations in light scattering caused by Brownian motion of suspended particles.

 

For Brownian diffusion, the frequency of scattered intensity fluctuations depends on the particle size; smaller particles diffuse more rapidly and thus produce higher frequencies. Therefore, the temporal fluctuations in light scattering hold information on the particle size.

 

 

Limitations conventional DLS

Standard DLS measurements need to be performed under static conditions ensuring that particle movement is solely caused by Brownian motion and not influenced by other factors like liquid flow.

 

Additionally, conventional DLS cannot be applied to relative turbid suspension without dilution, while these are often encountered in industrial or process environments. Since nanosuspensions are in motion during processing and vary in turbidity levels conventional DLS is not very suitable for process analytics applications.

 

 

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Figure: Conventional DLS, nanoparticle size is measured by translation of light scatter frequencies caused by Brownian motion of suspended nanoparticles via auto-correlation functions; higher frequencies in scatter pattern relate to smaller particles due to their faster diffusion rate (Brownian motion). 

 

 


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Spatially Resolved Dynamic Light Scattering

To overcome the limitations of conventional DLS for process analytical applications InProcess-LSP developed a new innovative technology: Spatially Resolved Dynamic Light Scattering (SRDLS). SR-DLS allows particle size characterization in process flows and can measure highly turbid suspensions without dilution.

 

Low coherence interferometry

The NanoFlowSizer technology is based on low coherence interferometry providing light scattering information as a function of optical pathlength (pathlength or depth in the sample). 

 

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The depth-resolved light scattering holds information on particle movement caused by both Brownian motion as well as flow rate. The contribution due to Brownian motion is used for the calculation of the particle size characteristics, while the flow rate information is obtained instantaneously for every measurement as well.

 

 

Nanoparticle analysis of highly concentrated and optically turbid samples

The spatially resolved data in combination with smart algorithms allows the NanoFlowSizer to distinguish single from multiple scattered light, which is fully automated within the XsperGo software. As a result, obtained data of highly turbid samples is automatically corrected for multiple scattered light (since multiple scattered light will not be used for adequate particle size analysis in DLS). 

 

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Figure: Left: the chance that unwanted multiple scattering occurs increases with the turbidity level of the sample and the pathlength of the light. When multiple scattering occurs, the applied algorithms of the NanoFlowSizer will detect automatically at which depth (pathlength) this occurs. Middle: the obtained auto-correlation functions originated form single scattered light are automatically selected, for processing of particle size information, while those related to multiple scattering are automatically discarded. Right: Particle size information is obtained by processed single scattered light data only.

 

The measurement and processing of the data into particle size information, such as z-average, PSD (particle size distribution) and PDI (poly dispersity index), takes place within 10s. 

 

 

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