The ScreenChip™ System

Synchronize and Associate Visual Phenotypes with Feeding Behavior 

 

 

 

 

To understand the mechanisms of action of your proteins or drugs, it is important to understand the behaviors (social behaviors, reward behaviors, sickness behaviors, and avoidance behaviors) of overall worm populations as well as phenotypes (specific phenotypes such as unc, dpy, dumpy, RNAi, and blister) that reveal the underlying cellular and molecular forces in action. The ScreenChip™ System, along with the WMicrotracker System, allow you to get in-depth understanding of worm behavior.

 

The ScreenChip™ System, a C. elegans visual screening and phenotyping platform allows you to associate visual phenotypes with feeding behavior.

 

•  Measure, visualize and analyze the neuromuscular aspects of feeding behavior

•  Assess the neuronal and physiological responses to drugs, aging, genetic modifications or environmental changes (Fig. 1 & 2)

•  Perform multiple phenotyping analyses at once, i.e., morphology, fluorescence, defecation, and feeding behavior while your worm is immobilized in the chip

•  Eliminate experimenter’s bias and get more reproducible data 

 

 

 

 

 

- No mounting and single-worm manipulation 

 

- No previous C. elegans experience required 

 

- Automated data collection and analysis 

 

 

 

 

Video perfectly synchronized with EPG traces

 

 

 

 

What exactly wrong is with my worm?                                Data output from the ScreenChip System

 

 

 

 

 

 

Select What you want to see 

 

 

 

 

Applications

 

1. Aging

 

Aging phenotypes observed as changes in EPG trace

 

 

2.  Disease Modeling

 

Humanized worm recapitulates function and physiology

 

 

3.  Compound Testing

 

Visualize whole-worm pharmocological effects via EPG 

 

 

 

 

The ScreenChipTM System can also be used in the field of toxicology to quantify adverse effects of chemical substances (e.g., environmental pollutants, drugs) on living organisms. 

 

 

 

Cat. No.	Product	Unit
SKC101A, SKC102A	ScreenChip System *	1
SC10, SC20, SC30, SC40, SC60, SCX1, SX99	ScreenChip Cartridges	Box of 10
WREC01	Worm Recovery Kit	1
VAC100	Vacuum Pump	1

 

 

* The ScreenChip System includes:

   •  1 ScreenChip System

   •  1 HD camera (monochrome or color)

   •  1 C-mount or CS-mount microscope adapter

   •  1 cable set

   •  Data acquisition and data analysis software license

   •  Free software updates

   •  Chip sampler

• ScreenChip System Software
• How-to Videos
• FAQs
• Troubleshooting Guide
• User Guide 
• Protocols