Fluidity One-W Serum
Binding affinity measurement in Serum
using microfluidic diffusional sizing (MDS)
• Characterization of protein interactions in solution using microfluidic
diffusional sizing (MDS)
• Ability to measure in complex backgrounds such as minimally diluted serum
• No binding artifacts or non-specific binding, no surface-constraints
• Independent determination of antibody concentration and affinity for a
comprehensive immune response assessment
• Easy-to-use interface and consumable management
• Disposable single use chips and contained waste minimize risk of cross
• Research use only
Quantification of protein interactions
Characterization and quantification of antigen-antibody interactions directly in minimally diluted serum
Fingerprints of affinity and concentration in real time
Independent determination of antibody affinity and concentration for comprehensive immune response assessments in real time
In-solution measurements in complex backgrounds
Elimination of non-specific binding and other binding artifacts for accurate characterization of protein interactions
We have developed a new instrument that enables comprehensive profiling of the antibody response
to SARS-CoV-2 on the basis of affinity—a crucial characteristic of protein interactions that
traditional antibody tests cannot easily quantify.
In-solution affinity profiling directly in minimally diluted serum Ability to independently
determine antibody affinity and concentration
Characterize protein interactions in complex backgrounds
Determine antibody affinity (antibody binding strength) and concentration directly in patient serum for a comprehensive immune response assessment.
Measure in complex backgrounds
Characterize protein interactions in biological mixtures such as crude lysates, plasma without surface constraints or binding artifacts.
How does the Fluidity One-W Serum compare to other techniques
Our approach uses in-solution measurements to eliminate the many drawbacks of immobilized assays including non-specific binding and binding artifacts.
As a result, our assays can be run in native complex backgrounds like minimally diluted serum to better predict in-vivo performance.
Disposable Microfluidic Chips
Single-use injection molded chips for use with the Fluidity One-W.
The chips are designed to house the microfluidic channels to ensure reliability and reproducibility of results.
The microfluidic chips for the fluidity One-W are sold as part of a consumable pack with reagent cartridges. These packs come in 2 sizes:
• Small – 4 chip boxes (total 96 chips) and one reagent cartridge.
• Medium – 12 chip boxes (total 288 chips) and 3 reagent cartridges.
Fluidity One disposible microfluidic chips are bundled with sufficient reagents cartridges for the number of chips you order. These cartridges contain everything you need to perform Microfluidic Diffusional Sizing on the Fluidity One–W and Fluidity One-W Serum.