인성크로마텍 로고

검색버튼
퀵메뉴 펼침

o
p
e
n
c
l
o
s
e

Aura™
제품명: Aura™
용도: High-Throughput Particle Counting, Sizing, and ID
메이커: Halo Labs
카달로그: 다운로드


소개

 

Aura-hero-left_no_BG_w_shadow-300x271.png

Aura 

High-Throughput Particle Counting, Sizing, and ID

 

 

 

•  Particle ID

•  5 uL - 10 mL Sample Volume

•  1 Minute Per Sample

•  100% Sampling

 


 

 

The Aura™ system takes the guesswork out of your particle analysis so you’ll know exactly how to get to your best formulation. Fluorescence Membrane Microscopy (FMM) technology tells you which particles are protein aggregate and which are extrinsic non-particle protein while an optional second fluorescence channel enables custom fluorescence assays that can identify other molecules specific to your process.

 

Combine this with the Backgrounded Membrane Imaging (BMI) technology that powers the Horizon system for a low volume, high-throughput subvisible particle analysis system. Translation? You can now perform particle screening as early as lead optimization and pre-formulation testing to gain key drug stability insights earlier, reducing development risk and time to market. And did we mention the Aura counts and measures 100% of your sample so sample focus and flow rates won’t ever bias your data? With Aura, you’ll never need to worry about what you’re missing!

 

 

FMM: how it works BMI: How it works

 

 

 

 

                                                             Why Aura? 

 

 

 

Know What’s Protein And What’s Not

 

Definitively determine if your particles are protein or not in your stability analysis and contaminant detection by using Thioflavin T, a fluorescent dye that specifically binds to protein aggregates.

 

 

FMM-overlay-1.png

 

 

 

 

 

Fluorescence Labeling Of Your Choice

 

Get the flexibility needed to identify other particles in your formulation. Choose between channels for TMA, Bodipy, DiI, to identify hydrophobic entities or other molecules specific to your process. Don’t see the channel you want? Select your own custom excitation and emission!

 

 

dye_tubes.jpg

 

 

 

Minimal Optimization

 

Only the Aura system measures 100% of your sample and keeps all of the particles in the same plane of focus. Get accurate counts right away, without having to optimize the frame rate and flow rate.

 

Black-96-well-plate.png

 

 

 

Full Automation

 

Looking for ways to increase your efficiency? Not only is the 96-well membrane plate compatible with liquid handlers, but the Aura system is fully robotic-compatible as well.

 

 

 

Aura-hero-right-845x684.png

 

 

 

Large Size Range

 

1 µm – 5 mm. See the smallest subvisible to the largest visible particles, all in one tool.

 

 

Brightfield-vs-diameter.jpg

 

 


 

                                       Aura in Your Lab 

 

 

 

Protein/Non-protein ID

Distinguish between protein and non-protein particles with fluorescence detection.

 

Learn More

 

 

High Concentration Samples

Ideal for antibody particle analysis or any limited material samples with high viscosity and high refractive index.

 

 

Particle Classification

Distinguish degraded polysorbate particles, protein silicone oil aggregates, glass, plastic, fibers, aggregated proteins, and more!

 

 

Analytical Development and Quality Control

Particle identification assists with forensics. 21 CFR Part 11 software available. 

 

Learn More