SiliaBond for Organic Synthesis 소개 및 선택 가이드

 

Discover How our Reagents & Oxidants Can Optimize your Synthesis

Increasingly, the use of heterogeneous reagents in organic synthesis and chemical production is growing in importance. This technology is completely in line with the industries seeking improved sustainability and reduced ecological footprint. This strong trend is directly derived from the inherent benefits offered by silica-based heterogeneous reagents & oxidants:

• Extremely easy product / API isolation and purification (simple & quick filtration of the heterogeneous support)

• Eliminates or strongly reduces the need for laborious purifications

• No leaching of silica or catalyst and no cross contamination

• Highly suitable for either batch or continuous flow applications

• Convenient for high throughput medicinal & discovery chemistry

• Improved reactivity & selectivity over homogeneous reagents / catalyst

• Compares very favourably to polymer-based reagents: no swelling, thermally stable, more easily scalabe, faster kinetics, compatible with all solvents 

  and mechanically stable.

 

Here are a selection of reactions that can be done using our reagents and oxidants:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

SiliaBond Reagents & Oxidants  선택 가이드 

 

Typical Reaction	Best SiliaBond Reagent or Oxidant / SiliaCat SiliaCat Catalyst
Acylation / Esterification	SiliaBond DMAP SiliaBond AlCl3 SiliaBond Tosic Acid
Alkylation / Etherification	SiliaBond Guanidine SiliaBond AlCl3
Amide Coupling (with acids, acid chlorides and amines)	SiliaBond Carbodiimide SiliaBond EDC
Catalytic Hydrogenation	SiliaCat Pd0 SiliaCat Pt0
Coupling Reactions Buchwald Amination, Heck, Kumada, Negishi, Sonogashira, Stille & Suzuki Couplings and more...	SiliaCat DPP-Pd SiliaCat Pd0
Deprotection of Aromatic Ether	SiliaBond Tosic Acid
Ether Formation	SiliaBond AlCl3 SiliaBond Tosic Acid
Fmoc, Bsmoc Deprotection of Amino Acid	SiliaBond Piperazine
Friedel-Crafts Alkylation	SiliaBond AlCl3
Fries-Speier Esterification	SiliaBond Tosic Acid
Knoevenagel Condensation	SiliaBond Amine SiliaBond Dimethylamine SiliaBond Piperidine SiliaBond Piperazine
Michael Addition	SiliaBond Dimethylamine SiliaBond Guanidine
Nitro-Aldol (or Henry) Reaction	SiliaBond Carbonate
Oxidation (Alcohols to acids)	SiliaBond KMnO4
Oxidation (Alcohols to ketones / aldehydes)	SiliaCat TEMPO SiliaBond PCC SiliaBond PDC
Reduction (Reductive Amination, Alkylation, etc.)	SiliaBond Cyanoborohydride
Sulfonamide Synthesis	SiliaBond EDC
Tosylate Formation	SiliaBond Tosyl Chloride
Urea Synthesis	SiliaBond DMAP
Williamson Ether Synthesis	SiliaBond Guanidine