E-PAK®   Fixed Bed Flow-Through Purification Cartridges

 

E-PAK is a family of radial flow adsorption cartridges developed specifically for pharmaceutical processing.

Offered with a choice of metal scavengers, bare silica & activated carbons, these cartridges are designed to 

remove precious metal catalysts, reaction-by-products or color from synthetic reaction mixtures and natural products.

• Easy Scale-Up

  From laboratory to industrial production

• Proven Technology

  Proven cartridge design & reliable technology

• Performance

  High adsorption capacity & flow rate

• Convenience

  Safer handling, clean-up & disposal

• Optimization

  Increases product recovery & reduces solvent requirements

• Various Sorbents Offered

  SiliaMetS Metal Scavengers, Bare Silica & Activated Carbons 

 

 

 

E-PAK Cartridges Portfolio

E-PAK Cartridges are offered in 3 formats:

 

Lab ScalePilot ScaleCommercial Scale

With 3 types of sorbents :

 •  SiliaFlash irregular silica gels

    40 - 63 µm

    60 - 200 µm

    200 - 500 µm

 •  Metal Scavengers

    SiliaMetS Thiol

    SiliaMetS DMT

 •  Activated Carbons

    C941

    C-947

    C948

We also offer a range of housings for each cartridge format :

E-PAK Cartridge Housings

 

 

 

 

 

Available Sorbents

Active Adsorbents	For Removal and/or Recovery of :	pH Operation
SiliaMetS Thiol	Pd, Ag, Hg, Os, Ru, Cu, Ir, Pb, Rh, Se & Sn	2 to 10
SiliaMetS DMT	Pd, As, Ir, Ni, Os, Pt, Rh, Ru Se, Cd, Co, Cu, Fe, Sc & Zn
SiliaMetS Imidazole	Cd, Co, Cu, Fe, Ir, Li, Mg, Ni, Os, W, Zn, Cr, Pd & Rh
SiliaBond Amine	Pd, Cr, Pt, W, Zn, Cd, Co, Cu, Fe, Hg, Ni, Pb, Ru, Sc & Se
SiliaMetS Diamine
SiliaMetS Triamine
SiliaFlash Bare Silica	Very vast range of organic impurities, metals, pigments...	2 to 9
Activated Carbons	Precious metal catalysts & colors	1 to 13

 

 

 

Scale Up

One of the strongest benefits of SiliCycle E-PAK Cartridges is their linearity upon scale-up.As shown below, in a typical Suzuki-Miyaura coupling for which palladium needed to be removed, each format behaved very similarly in terms of efficiency (scavenging %), kinetics and relative capacity.

 

 

 

 

 

Experimental Conditions
E-PAK Format	Bead volume (mL)	Flow rate (mL/min)	Residence Time (min:sec)
5 cm x 1 cm	18.8	10	01:53
5 cm x 12 cm	188	100	01:53
5 cm x 25 cm	470	250	01:53
16.5 cm x 25 cm	4,750	2,600	01:50
16.5 cm x 100 cm	19,000	10,400	01:50

 

 

 

 

Once the best purifications sorbents have been identified in bulk, transferring the conditions from bulk to cartridges can be a very robust strategy for rapid and efficient scale-up.

 

Various Ways of Using E-PAK

Depending on the application and how you prefer to work, E-PAK cartridges can be used in different ways as shown below.

 

For a single pass usage, we suggest to run at very low flow rate compared to recirculation process, which can be run at higher flow rate. 

 

 

 

 

 

 

Flow & Hydraulic Pressure Drop

Cartridges provide rapid kinetics at flow rates and contact times suitable for single pass operation. The chart below shows typical flow rates and pressure drop performance for Lab, Pilot and Commercial Scale Cartridges.

Cartridge Size (diameter x height)	Minimum Flow Rate	Maximum Flow Rate	Pressure Drop ΔP (Psig) with w/1 cps Fluid
5 x 1 cm (Lab)	5 mL/min	100 mL/min	≤ 7.5 psig
5 x 10 cm (Lab)	50 mL/min	500 mL/min	≤ 5 psig
5 x 25 cm (Lab)	125 mL/min	1 L/min	≤ 5 psig
16.5 x 12.5 cm (Pilot)	0.95 L/min	2.5 L/min	≤ 10 psig
16.5 x 25 cm (Pilot)	1.9 L/min	5 L/min	≤ 10 psig
16.5 x 50 cm (Commercial)	3.8 L/min	10 L/min	≤ 10 psig
16.5 x 100 cm (Commercial)	7.6 L/min	20 L/min	≤ 10 psig

 

 

 

Chemical Compatibility

E-PAK cartridges are formed using a proprietary technology and chemically stable materials in common organic solvents.

E-PAK cartridges have been tested and found satisfactory for use with the following commonly used solvents:

• Methanol

• Dichloromethane

• Ethyl acetate

• Tetrahydrofuran

• Toluene

• N-ethyl-2-pyrolidone

E-PAK cartridges are suitable for operation at pH of 1 to 13 for activated carbon and 2 to 12 for silica-based products. 

 

 

 

Handling and Safety

Initial solvent wetting of E-PAK cartridges will produce heat; a risk assessment with the use with low vapor pressure solvents is recommended.

The adsorbent matrix in E-PAK cartridges is electrically conductive. E-PAK cartridges filter housings and retrofit kits provide a connection between the adsorbent matrix and the filter cartridge housing. A risk assessment of electrical discharge in explosion proof environments is recommended.

 

 

Quality and Regulatory

E-PAK cartridges are manufactured under ISO 9001, GMP manufacturing operations in Glasgow, DE (U.S.A.).

Drug Master File registrations are in progress. 

 

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