Adulterant Control      Controls 

 

A validity control, which contains common adulterants, is utilized in drugs of abuse (DOA) testing to confirm a laboratory's DOA analytical systems are performing accurately and can identify adulterated urine specimens. Validity Controls Level 1 through 5 are used as quality control materials to help identify substituted, diluted, and adulterated urine samples. 

The matrices for this QC are prepared from distilled water. The levels of the Adulterants, Creatinine, Specific Gravity, and pH are adjusted to the desired range for each lot prepared. Quality control before, during, and after the preparation of the control material insures that each lot is comparable and of the same high quality. The listed ranges were verified by analytical methods similar to those actually used in a testing laboratory. 

 

 

 

Validity Control Level 1 

Analyte	Gravimetrically Weighted Value	Units	Stability (Days)
Chromium VI	n/a	µg/mL	n/a
Creatinine	n/a	mg/dL	n/a
Nitrites	500 - 625	µg/mL	n/a
Oxidants	n/a	µg/mL	n/a
pH	4.5 - 9.0		n/a
Specific Gravity	1.0010 - 1.0027		n/a

 

 

Validity Control Level 2

Analyte	Gravimetrically Weighted Value	Units	Stability (Days)
Chromium VI	0	µg/mL	n/a
Creatinine	1.0 - 1.5	mg/dL	n/a
Nitrites	0	µg/mL	n/a
Oxidants	0	µg/mL	n/a
pH	3.2 - 4.0		n/a
Specific Gravity	1.0210 - 1.0250		n/a

 

Validity Control Level 3

Analyte	Gravimetrically Weighted Value	Units	Stability (Days)
Chromium VI	n/a	µg/mL	n/a
Creatinine	3.0 - 4.0	mg/dL	n/a
Nitrites	200 - 250	µg/mL	n/a
Oxidants	n/a	µg/mL	n/a
pH	10.0 - 10.8		n/a
Specific Gravity	0.9950 - 1.0005		n/a

 

 

Validity Control Level 4

Analyte	Gravimetrically Weighted Value	Units	Stability (Days)
Chromium VI	n/a	µg/mL	n/a
Creatinine	21 - 25	mg/dL	n/a
Nitrites	n/a	µg/mL	n/a
Oxidants	n/a	µg/mL	n/a
pH	2.0 - 2.8		n/a
Specific Gravity	1.0040 - 1.0180		n/a

 

 

Validity Control Level 5

Analyte	Gravimetrically Weighted Value	Units	Stability (Days)
Chromium VI	>65	µg/mL	n/a
Creatinine	n/a	mg/dL	n/a
Nitrites	n/a	µg/mL	n/a
Oxidants	>65	µg/mL	n/a
pH	11.2 - 12.0		n/a
Specific Gravity	n/a		n/a

Matrix	Adulterant
Unit Size	1x25mL
Form	Liquid
Shelf Life	24 months
Stability	n/a
Storage	Store liquid control material at 2-8ºC (35-46ºF).

17010         Validity Control Level 1         1 x 25 mL

17011         Validity Control Level 2         1 x 25 mL

17012         Validity Control Level 3         1 x 25 mL

17013         Validity Control Level 4         1 x 25 mL

17014         Validity Control Level 5         1 x 25 mL

Validity SDS | Download PDF