SiliaMetS® Metal Scavengers
Metallic impurities removal, under all formats (bulk, prepacked, flow), at any scale (from lab to production)
Largest portfolio of grafted scavengers on the market and the largest spectrum of functionalities. All SiliaMetS / SiliaBond Scavengers can be used in a pH range of 2 to 12 and most of them can withstand temperatures up to 150°C. Standard scavengers are grafted on 40 - 63 µm, 60 Å silica gel. All functionalities are also available on any other of our bare silica gels, with various particle and pore diameters.
• Over 20 years of know-how in metal scavenging
• Strong, extensive, and confidential technical support
• Broad variety of ligands
• Wide range of formats for all purification scales;
from laboratory to plant purifications
• Competitive prices
What are SiliaMetS Metal Scavengers?
SiliaMetS Metal Scavengers are functionalized silica gels designed to react and bind metal complexes. The process for using scavengers is outlined in the scheme
To be effective, the Metal Scavengers need the ability and inherent functionality to remove metals in their various oxidation states from the reaction mixture. For example, upon completion of a palladium metal-catalyzed reaction, the metal residue contained in the reaction can exist in both Pd(0) and Pd(II).
Metal Scavengers Selection Guide
The following selection table, shown below, helps customers in selecting the most efficient scavenger for a specific metal and application. However, since some parameters may affect the efficiency of the scavenging, we highly recommend performing a preliminary screening experiment using the SiliaMetS Metal Scavengers kit.
Best Scavenger Good Scavenger
In recent years, the time pressure associated with quickly bringing candidate drugs to market has increased the number of transition metal-catalyzed reactions being transferred from lead optimization to early scale-up. The removal of post-reactions metal residues has become a major issue in the pharmaceutical industry. Purification of APIs from residual metal catalyst by traditional methods (chromatography, activated carbon, distillation, etc.) often leads to problems such as high costs, time loss, low efficiency, and reduced API yields. To overcome these limitations, SiliCycle has developed SiliaMetS Metal Scavengers, a range of products that have significantly changed how chemists can purify APIs.
Silica-based metal scavengers have been proven to be the purification method of choice over all other methods and several companies from various industries use them. Take a look at our Case Studies to read about satisfied customers. With the silica matrix advantages over polymers (no swelling, more general solvent compatibility, higher mechanical and thermal stabilities, applications easily scalables and products available in different formats (SPE, flash cartridges and bulk), etc.) combined to SiliCycle's expertise in grafting technology, SiliaMetS are the solution for metal removal without contamination of drug candidates. SiliaMetS are highly selective and offer a cost-effective alternative for metal scavenging.
• No leaching
No API contamination by the metal scavenger
• Very High Purity
Each SiliaMetS product manufactured is submitted to a very rigorous quality control in order to provide customers
with default-free products and insure 100% satisfaction
• High Selectivity
Total recovery of the API
• Wide Range of Metal Affinities (various oxidation state)
Efficient for a wide range of metal catalysts
• Fast Kinetic
Even at room temperature
• Cost Efficient
Low cost per gram of metal scavenged
Less solvent used
• Solvent Compatibility
Can be used in any solvent, aqueous (pH 2 to 12) and organic
• New Technologies Compatibility
Suitable for use in microwave synthesizers and flow chemistry
• Excellent Stability (Thermally and Mechanically)
Works well with overhead stirring
Can withstand very high temperatures
• Ease of Use & Scalable
No swelling or static charge
Remove easily from a simple filtration
Scalable from mg up to multi-ton scale
• Flexible Formats
Amenable to use in SiliaSep & SiliaPrep Cartridges
• Controlled Loading
Consistent and accurate loading insure lot-to-lot reproducibility
• Available at Bulk Quantities
Proced in large quantities and always in stock