Premade Human Antibody Library for Yeast Display

Scientists in Creative Biolabs have constructed a series of high quality yeast surface-displayed human antibody libraries for de novo discovery of therapeutically relevant antibodies. They’re available for license or contract service.

Table 1: Premade Human Antibody Libraries

These libraries have a size ranging from 10^6 to 10^11 and cover most commonly used antibody formats, including scFv, Fab, scFab, full-length IgG and Fn3. Comprehensive library types and various genetic backgrounds give these libraries multiple functions and applications. In combination with the Ultraff™ Yeast Display Technology or Yeast Mating Technology from Creative Biolabs, low nanomolar, even picomolar-affinity antibodies of different formats are routinely obtained. All human antibody libraries for yeast display licensed from Creative Biolabs can be amplified 1010 fold under proper operation, without measurable loss of clonal diversity, allowing effectively indefinite expansion. Creative Biolabs’ top quality human antibody libraries for yeast display can improve your results and save your time in novel antibody discovery.

Figure 1. Four types of antibody libraries (Ref: High Affinity, Developability and Functional Size: The Holy Grail of Combinatorial Antibody Library Generation)

Advantages of Yeast Display :

  •   Eukaryotic expression and processing

  •   Quality control mechanisms of the eukaryotic secretary pathway

  •   Minimal avidity effects

  •   Quantitative library screening through FACS

  •   Complex post-translational modifications 

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