Cytokines

 

Cytokines are small, secreted proteins that have a specific effect on the interaction, communication, or behavior of cells. Although putative cytokines have been identified in many invertebrates species, including Spatzle and Unpaired in Drosophila and Insect chemotactic peptide in the moth, the majority of cytokines utilized by modern day vertebrates most likely evolved after the split from invertebrate lineages, coincident with the development of adaptive immunity. Proinflammatory cytokines, such as interleukin (IL)-17A and interferons, evolved early during the evolution of lower vertebrates, while regulatory and immunosuppressive cytokines, such as IL-4 and IL-10, are thought to have evolved more recently. In vertebrates, cytokines play a pivotal role in the maintenance of homeostasis and in the coordination of innate and adaptive immune responses.

 

Chemokines

CCL1CCL11CCL12CCL13CCL14CCL15CCL16CCL17CCL18CCL19CCL2CCL20 

CCL21CCL22CCL23CCL24CCL25CCL26CCL27CCL28CCL3CCL4CCL5CCL6 

CCL7CCL8CCL9CX3CL1CXCL1CXCL10CXCL11CXCL12CXCL13CXCL14CXCL15 

CXCL16CXCL16CXCL2CXCL3CXCL4CXCL5CXCL6CXCL7CXCL8CXCL9

 

 

Chemokine receptors 

CCR1CCR10CCR2CCR3CCR4CCR5CCR6CCR7CCR8CCR9 CXCR1CXCR2CXCR3CXCR4CXCR5CXCR6XCR1

 

Interleukins 

 

IL-2IL3IL-7IL3RIL5RIL2RIL10IL27IL-1IL-10IL-11

 

TNF Superfamily

TNFSF13BCD137CD153CD30LTNFSF8CD27CD70CD27LTNFSF7CD95 APO1TNFRSF6CDIP1DcR3TNFRSF6B

EDARGITRTNFRSF18HVEMTNFRSF14 MIPOL1OX-40LTNFSF4CD252RANKLOPGLTNFSF11CD254TACI

TNFRSF13B CD267TANKTL1ATNFSF15TNF-alphaTNFATNF-betaTNFSF1Lymphotoxin alpha TNFAIP2TNFAIP8

TNFR1CD120aTNFRSF1A

Jak

JAK1   JAK2   JAK3 

 

STAT

Cytokine 제품 상세 보기