LCMS Grade Solvents    Mobile Phase Solvents

 

Using ProteoChem's LCMS Grade Solvents, scientists can expect a consistent, high purity product which is necessary to create reliable mass spectrometry and chromatography methods and protocols. Each lot of solvent is analyzed to ensure ultra-low metal abundance, UV absorbances are minimal, and that other ionizable materials are minimized; which can be critical in assuring maximum mass spectrometry sensitivity.

 

    LCMS Acetonitrile

    LCMS Acetonitrile with 0.1% Acetic Acid v/vLCMS Acetonitrile with 0.1% Acetic Acid v/v

    LCMS Acetonitrile with 0.1% Formic Acid v/v

    LCMS Acetonitrile with 0.1% TFA v/v

    LCMS Acetonitrile with 0.1% Formic Acid and 0.01% TFA v/v

    LCMS Methanol

    LCMS Water

    LCMS Water with 0.1% Acetic Acid v/v

    LCMS Water with 0.1% Formic Acid v/v

    LCMS Water with 0.1% TFA v/v

    LCMS Water with 0.1% Formic Acid and 0.01% TFA v/v

    LCMS Isopropyl Alcohol 

 

1.  LCMS Acetonitrile

Applications for LCMS AcetonitrileLCMS grade Acetonitrile (ACN) solvent from ProteoChem is well suited for both reverse and normal phase LCMS applications. LCMS Acetonitrile is an ideal mobile phase solvent for separation of peptides or proteins in reverse phase liquid chromatography and mass spectrometry (HPLC-MS). ProteoChem's LCMS Acetonitrile purity is ≥ 99.9% to allow maximum sensitivity of your assay.

All of ProteoChem's LCMS solvents are lot tested to ensure minimized levels of signal suppressing contaminants and low evaporative residue levels. ProteoChem's LCMS Acetonitrile also allows for high sensitivity detection at a wide range of UV detection wavelengths, including the low UV wavelengths, where many other solvent brands contain interferents. Each lot of ProteoChem's LCMS grade Acetonitrile is tested to ensure suitability in LCMS and HPLC functions, making this product an ideal choice for instruments that perform both chromatography and mass spectrometry.

 

•  ProteoChem also offers an exceptionally high purity HPLC grade Acetonitrile.

•  Molecular Formula: C2H3N

•  Molecular Weight: 41.05

•  Density: 0.786 g/mL

•  CAS Number: 75-05-8

•  Alternative Names: Methyl cyanide; Cyanomethane; Ethanenitrile; LC-MS Acetonitrile; LC/MS Acetonitrile, LC/MS ACN, LCMS ACN, MS grade Acetonitrile 

 

 

 

 

2.  LCMS Acetonitrile with 0.1% Acetic Acid v/vLCMS Acetonitrile with 0.1% Acetic Acid v/v

CMS grade Acetonitrile with 0.1% Acetic Acid v/v from ProteoChem is well suited for reverse phase LCMS applications. LCMS Acetonitrile with 0.1% Acetic Acid v/v allows for easy mobile phase preparation by already having the Acetic Acid additive already added to the solvent. The presence of Acetic Acid in both the organic and aqueous components of the mobile phase allows for optimal pH stability in LCMS applications. ProteoChem's LCMS Acetonitrile with 0.1% Acetic Acid v/v purity is highly refined to allow maximum sensitivity of your assay.

All of ProteoChem's LCMS solvents are lot tested to ensure minimal levels of signal suppressing contaminants and low evaporative residue levels. ProteoChem's LCMS Acetonitrile with 0.1% Acetic Acid v/v also allows for high sensitivity detection at a wide range of UV detection wavelengths, including the low UV wavelengths, where many other solvent brands contain interferents. Each lot of ProteoChem's LCMS Acetonitrile with 0.1% Acetic Acid v/v is tested to ensure suitability in LCMS and HPLC functions, making this product an ideal choice for instruments that perform both chromatography and mass spectrometry.

Alternative Names: LC-MS Acetonitrile (ACN) with 0.1% Acetic Acid v/v; LC/MS Acetonitrile with 0.1% Acetic Acid v/v; MS grade Acetonitrile with 0.1% Acetic Acid v/v 

3.  LCMS Acetonitrile with 0.1% Formic Acid v/v

LCMS grade Acetonitrile with 0.1% Formic Acid v/v from ProteoChem is well suited for reverse phase LCMS applications. LCMS Acetonitrile with 0.1% Formic Acid v/v is an ideal mobile phase solvent for separation of peptides or proteins in reverse phase liquid chromatography and mass spectrometry (HPLC-MS). Formic Acid provides many advantages over TFA, in LCMS applications, in that Formic Acid does not strongly pair with peptides or other organic compounds. Formic Acid provides good pH stability, allowing for better separations, while not inhibiting ionization. ProteoChem's LCMS Acetonitrile with 0.1% Formic Acid v/v is highly pure to allow maximum sensitivity of your assay.

All of ProteoChem's LCMS solvents are lot tested to ensure minimized levels of signal suppressing contaminants and low evaporative residue levels. ProteoChem's LCMS Acetonitrile with 0.1% Formic Acid v/v also allows for high sensitivity detection at a wide range of UV detection wavelengths, including the low UV wavelengths, where many other solvent brands contain interferents. Each lot of ProteoChem's LCMS Acetonitrile with 0.1% Formic Acid v/v is tested to ensure suitability in LCMS and HPLC functions, making this product an ideal choice for instruments that perform both chromatography and mass spectrometry.

Alternative Names: LC-MS Acetonitrile (ACN) with 0.1% Formic Acid v/v; LC/MS Acetonitrile with 0.1% Formic Acid v/v; MS grade Acetonitrile with 0.1% Formic Acid v/v; Mass Spectrometry Grade Acetonitrile with 0.1% Formic Acid 

 

4.  LCMS Acetonitrile with 0.1% TFA v/v

LCMS grade Acetonitrile with 0.1% TFA v/v from ProteoChem is well suited for reverse phase LCMS applications. LCMS Acetonitrile with 0.1% TFA v/v is an ideal mobile phase solvent for separation of peptides or proteins in reverse phase liquid chromatography and mass spectrometry (HPLC-MS). ProteoChem's LCMS Acetonitrile with 0.1% TFA v/v is highly pure to allow maximum sensitivity of your assay.

 

Trifluoroacetic Acid (TFA) is well known as the additive of choice for optimal HPLC separation of peptides. TFA provides an ion pairing effect for peptides that inhibit band diffusion associated with peak tailing, which often times allows for more efficient separation of peptide analytes. Having TFA in both the organic phase and the aqueous phase of an HPLC-MS system allows for high levels of pH stability and additive concentrations.

 

ProteoChem also offers an exceptionally high purity HPLC Grade Acetonitrile with 0.1% TFA v/v.

 

All of ProteoChem's LCMS solvents are lot tested to ensure minimized levels of signal suppressing contaminants and low evaporative residue levels. ProteoChem's LCMS Acetonitrile with 0.1% TFA v/v also allows for high sensitivity detection at a wide range of UV detection wavelengths, including the low UV wavelengths, where many other solvent brands contain interferents. Each lot of ProteoChem's LCMS Acetonitrile with 0.1% TFA v/v is tested to ensure suitability in LCMS and HPLC functions, making this product an ideal choice for instruments that perform both chromatography and mass spectrometry.

 

Alternative Names: LC-MS Acetonitrile (ACN) with 0.1% Trifluoroacetic acid v/v; LC/MS Acetonitrile with 0.1% TFA v/v; MS grade Acetonitrile with 0.1% TFA v/v 

 

5.  LCMS Acetonitrile with 0.1% Formic Acid and 0.01% TFA v/v

LCMS grade Acetonitrile with 0.1% Formic Acid and 0.01% TFA v/v from ProteoChem is well suited for reverse phase LCMS applications. LCMS Acetonitrile with 0.1% Formic Acid and 0.01% TFA v/v is an ideal mobile phase solvent for separation of peptides or proteins in reverse phase liquid chromatography and mass spectrometry (HPLC-MS). ProteoChem's LCMS Acetonitrile with 0.1% Formic Acid and 0.01% TFA v/v is highly pure to allow maximum sensitivity of your assay.

 

This blend of TFA (0.01%) and Formic Acid (0.1%) is often employed to obtain the benefits of the ion pairing agent TFA, while not suffering significantly from its ion suppression effects. The presence of a 10 fold excess of Formic Acid effectively displaces TFA ion pairs enabling improved analyte ionization. By using this product along with LCMS Water with 0.1% Formic Acid and 0.01% TFA v/v, optimal pH and additive concentration control can be achieved, which is critical in creating a stable low level background noise environment.

 

All of ProteoChem's LCMS solvents are lot tested to ensure minimized levels of signal suppressing contaminants and low evaporative residue levels. ProteoChem's LCMS Acetonitrile with 0.1% Formic Acid and 0.01% TFA v/v also allows for high sensitivity detection at a wide range of UV detection wavelengths, including the low UV wavelengths, where many other solvent brands contain interferents. Each lot of ProteoChem's LCMS Acetonitrile with 0.1% Formic Acid and 0.01% TFA v/v is tested to ensure suitability in LCMS and HPLC functions, making this product an ideal choice for instruments that perform both chromatography and mass spectrometry.

 

Alternative Names: LC-MS Acetonitrile (ACN) with 0.1% Formic Acid and 0.01% TFA v/v; LC/MS Acetonitrile with 0.1% Formic Acid and 0.01% TFA v/v; MS grade Acetonitrile with 0.1% Formic Acid and 0.01% TFA v/v 

 

6.  LCMS Methanol

LCMS Methanol is an ideal mobile phase solvent for both reversed phase and normal phase HPLC-MS. ProteoChem's highly refined LCMS grade Methanol is ideally suited for even the most critical LCMS applications.

 

ProteoChem's LCMS Methanol purity is ≥ 99.9% pure, contains very low levels of evaporative residue, and other ion suppressing materials, which is critical to achieving maximum sensitivity with LC-Mass Spectrometry. LCMS Methanol is purified to minimize any UV impurities, which ensures high sensitivity and minimal interference in HPLC applications with UV detection.

 

•  ProteoChem also offers an exceptionally high purity HPLC grade Methanol.

•  Molecular Formula: CH4O

•  Molecular Weight: 32.04

•  Density: 0.7918 g/mL

•  CAS Number: 67-56-1

•  Alternative Names: Methyl Alcohol; LC-MS Methanol; LC/MS Methanol; Hydroxymethane; Methyl Hydrate; Carbinol; MeOH; LC/MS MeOH 

 

7.  LCMS Water

ProteoChem’s LCMS water is ideally suited for LC-MS and LC-MS/MS applications. Our highly refined LCMS grade water is tested for optimal HPLC and LCMS performance. ProteoChem’s LCMS water is designed to minimize LCMS noise caused by ionizable impurities, as well as provide a stable baseline for the highest sensitivity HPLC and LCMS applications.

 

ProteoChem also offers an exceptionally high purity HPLC Grade Water.

 

With ProteoChem's LCMS Grade Solvents, scientists can expect a consistent, high purity product which is necessary to create reliable mass spectrometry and chromatography methods and protocols. Each lot of solvent is analyzed to ensure ultra-low metal abundance, UV absorbances are minimal, and that other ionizable materials are minimized; which can be critical in assuring maximum mass spectrometry sensitivity.

 

•  CAS Number: 7732-18-5

•  Molecular Formula: H2O

•  Molecular Weight: 18.01

•  Alternative Name: LC/MS Grade Water; Water LCMS; Water LC/MS 

 

 

 

8.  LCMS Water with 0.1% Acetic Acid v/v

LCMS grade Water with 0.1% Acetic Acid v/v from ProteoChem is well suited for reverse phase LCMS applications. LCMS Water with 0.1% Acetic Acid v/v is an ideal mobile phase solvent for separation of peptides or proteins in reverse phase liquid chromatography and mass spectrometry (HPLC-MS). ProteoChem's LCMS Water with 0.1% Acetic Acid v/v is highly pure to allow maximum sensitivity of your assay.

 

0.1% Acetic Acid is a commonly used mobile phase in LCMS applications. ProteoChem has pre-blended this additive into the LCMS grade solvent to achieve optimal pH control and LCMS results. This "no-fuss" pre-blended product is often used with LCMS Acetonitrile with 0.1% Acetic Acid v/v

 

All of ProteoChem's LCMS solvents are lot tested to ensure minimized levels of signal suppressing contaminants and low evaporative residue levels. ProteoChem's LCMS Water with 0.1% Acetic Acid v/v also allows for high sensitivity detection at a wide range of UV detection wavelengths, including the low UV wavelengths, where many other solvent brands contain interferents. Each lot of ProteoChem's LCMS Water with 0.1% Acetic Acid v/v is tested to ensure suitability in LCMS and HPLC functions, making this product an ideal choice for instruments that perform both chromatography and mass spectrometry.

 

Alternative Names: LC-MS Water with 0.1% Acetic Acid v/v; LC/MS Water with 0.1% Acetic Acid v/v; MS grade Water with 0.1% Acetic Acid v/v 

 

9.  LCMS Water with 0.1% Formic Acid v/v

LCMS grade Water with 0.1% Formic Acid v/v from ProteoChem is well suited for reverse phase LCMS applications. LCMS Water with 0.1% Formic Acid v/v is an ideal mobile phase solvent for separation of peptides or proteins in reverse phase liquid chromatography and mass spectrometry (HPLC-MS). ProteoChem's LCMS Water with 0.1% Formic Acid v/v is highly pure to allow maximum sensitivity of your assay.

 

0.1% Formic Acid is a commonly used mobile phase additive. The addition of Formic Acid to a reversed phase mobile phase system allows for low pH control essential for many separations. This "no fuss" pre-blended mobile phase is often used with LCMS Acetonitrile with 0.1% Formic Acid v/v.

 

All of ProteoChem's LCMS solvents are lot tested to ensure minimized levels of signal suppressing contaminants and low evaporative residue levels. ProteoChem's LCMS Water with 0.1% Formic Acid v/v also allows for high sensitivity detection at a wide range of UV detection wavelengths, including the low UV wavelengths, where many other solvent brands contain interferents. Each lot of ProteoChem's LCMS Water with 0.1% Formic Acid v/v is tested to ensure suitability in LCMS and HPLC functions, making this product an ideal choice for instruments that perform both chromatography and mass spectrometry.

 

Alternative Names: LC-MS Water with 0.1% Formic Acid v/v; LC/MS Water with 0.1% Formic Acid v/v; MS grade Water with 0.1% Formic Acid v/v 

 

10.  LCMS Water with 0.1% TFA v/v

LCMS grade Water with 0.1% Trifluoroacetic acid (TFA) v/v from ProteoChem is well suited for reverse phase LCMS applications. LCMS Water with 0.1% TFA v/v is an ideal mobile phase solvent for separation of peptides or proteins in reverse phase liquid chromatography and mass spectrometry (HPLC-MS). ProteoChem's LCMS Water with 0.1% TFA v/v is highly pure to allow maximum sensitivity of your assay.

 

ProteoChem also offers an exceptionally high purity HPLC Water with 0.1% TFA v/v.

 

Triflouroacetic Acid (TFA) is a very popular mobile phase additive possessing both buffering and ion pairing capabilities. A 0.1% TFA solution in water is about pH 2, and 0.1% TFA in water is commonly used with LCMS Acetonitrile with 0.1% TFA v/v.

 

All of ProteoChem's LCMS solvents are lot tested to ensure minimized levels of signal suppressing contaminants and low evaporative residue levels. ProteoChem's LCMS Water with 0.1% TFA v/v also allows for high sensitivity detection at a wide range of UV detection wavelengths, including the low UV wavelengths, where many other solvent brands contain interferents. Each lot of ProteoChem's LCMS Water with 0.1% TFA v/v is tested to ensure suitability in LCMS and HPLC functions, making this product an ideal choice for instruments that perform both chromatography and mass spectrometry.

 

Alternative Names: LC-MS Water with 0.1% Trifluoroacetic acid (TFA) v/v; LC/MS Water with 0.1% TFA v/v; MS grade Water with 0.1% TFA v/v 

 

11.  LCMS Water with 0.1% Formic Acid and 0.01% TFA v/v

LCMS grade Water with 0.1% Formic Acid and 0.01% Trifluoroacetic acid (TFA) v/v from ProteoChem is well suited for reverse phase LCMS applications. LCMS Water with 0.1% Formic Acid and 0.01% TFA v/v is an ideal mobile phase solvent for separation of peptides or proteins in reverse phase liquid chromatography and mass spectrometry (HPLC-MS). ProteoChem's LCMS Water with 0.1% Formic Acid and 0.01% TFA v/v is highly pure to allow maximum sensitivity of your assay.

 

0.1% Formic Acid and 0.01% TFA is a commonly utilized HPLC-Mass Spectrometry mobile phase additive combination that utilizes TFA ion capabilities, while minimizing ion suppression in mass spectrometry detection. This combination of mobile phase additives is a common alternative to the "TFA Fix". This product is commonly used with LCMS Acetonitrile with 0.1% Formic Acid and 0.01% TFA v/v.

 

All of ProteoChem's LCMS solvents are lot tested to ensure minimized levels of signal suppressing contaminants and low evaporative residue levels. ProteoChem's LCMS Water with 0.1% Formic Acid and 0.01% TFA v/v also allows for high sensitivity detection at a wide range of UV detection wavelengths, including the low UV wavelengths, where many other solvent brands contain interferents. Each lot of ProteoChem's LCMS Water with 0.1% Formic Acid and 0.01% TFA v/v is tested to ensure suitability in LCMS and HPLC functions, making this product an ideal choice for instruments that perform both chromatography and mass spectrometry.

 

Alternative Names: LC-MS Water with 0.1% Formic Acid and 0.01% Trifluoroacetic acid (TFA) v/v; LC/MS Water with 0.1% Formic Acid and 0.01% Trifluoroacetic acid (TFA) v/v; MS grade Water with 0.1% Formic Acid and 0.01% Trifluoroacetic acid (TFA) v/v  

 

Cat. No	Product	Quantity
LC6310-1L	LCMS Acetonitrile	1 L
LC6310-4L	LCMS Acetonitrile	4 L
LC6310-4x4L	LCMS Acetonitrile	4 x4 L
LC6311-1L	LCMS Acetonitrile with 0.1% Acetic Acid v/v	1 L
LC6311-4x4L	LCMS Acetonitrile with 0.1% Acetic Acid v/v	4 x4 L
LC6312-1L	LCMS Acetonitrile with 0.1% Formic Acid v/v	1 L
LC6312-4L	LCMS Acetonitrile with 0.1% Formic Acid v/v	4 L
LC6312-4x4L	LCMS Acetonitrile with 0.1% Formic Acid v/v	4 x4 L
LC6313-1L	LCMS Acetonitrile with 0.1% TFA v/v	1 L
LC6313-4x4L	LCMS Acetonitrile with 0.1% TFA v/v	4 x4 L
LC6314-1L	LCMS Acetonitrile with 0.1% Formic Acid and  0.01% TFA v/v	1 L
LC6314-4x4L	LCMS Acetonitrile with 0.1% Formic Acid and  0.01% TFA v/v	4 x4 L
LC6320-1L	LCMS Methanol	1 L
LC6320-4L	LCMS Methanol	4 L
LC6320-4x4L	LCMS Methanol	4 x4 L
LC6330-1L	LCMS Water	1 L
LC6330-4L	LCMS Water	4 L
LC6330-4x4L	LCMS Water	4 x 4 L
LC6331-1L	LCMS Water with 0.1% Acetic Acid v/v	1 L
LC6331-4L	LCMS Water with 0.1% Acetic Acid v/v	4 L
LC6332-1L	LCMS Water with 0.1% Formic Acid v/v	1 L
LC6332-4L	LCMS Water with 0.1% Formic Acid v/v	4 L
LC6332-4x4L	LCMS Water with 0.1% Formic Acid v/v	4 x 4 L
LC6333-1L	LCMS Water with 0.1% TFA v/v	1 L
LC6333-4x4L	LCMS Water with 0.1% TFA v/v	4 x 4 L
LC6334-1L	LCMS Water with 0.1% Formic Acid and 0.01% TFA v/v	1 L
LC6334-4L	LCMS Water with 0.1% Formic Acid and 0.01% TFA v/v	4 L