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Human Parp-1 Assay Kit
제품명: Human Parp-1 Assay Kit
용도: Drug target and enzyme assays
메이커: ProFoldin
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소개

 

 

Human Parp-1 Assay Kit 

 

Drug target and enzyme assays

 

 

 

Poly (ADP-ribose) polymerase-1 (PARP-1) responses to DNA damage and synthesizes poly ADPribose (PAR) that is transferred to itself and a variety of acceptor proteins. Excessive activation of PARP-1 not only depletes NAD+ but also generates toxic PAR that lead to cell death. PARP-1 is an anti-cancer drug target. It is also a potential drug target for other diseases such as stroke, ischemia and reperfusion where high-level DNA damage occurs. 


The human PARP-1 assay is based on measurement of its product PAR (poly ADP-ribose) that binds to a fluorescent dye and enhances its fluorescent signal.

 

 

 

 

 

Human Parp-1 Assay.PNG

 

 

 

 

 

The Human Poly (ADP-ribose) Polymerase-1 Assay Kit (catalog number PAR100K) 


Includes 800 μl of 10x the assay buffer, 55 μl of 100x NAD+, 55 μl of 100x DNA and 220 μl of 100 x fluorescence dye for 100 assays of human PARP-1 in a 96-well plate format. The kit does not include Human PARP-1.



 

Human Poly (ADP-ribose) Polymerase-1 Assay Kit Plus (catalog number PAR100KE) 


Includes 800 μl of 10 x the assay buffer, 55 μl of 200x NAD+, 55 μl of 100x DNA, 17 μl of 300 x Human PARP-1 and 220 μl of 100x fluorescence dye for 100 assays of human PARP-1 in a 96-well plate format.