Concentration assays for Carfilzomib / Cisplatin / Ciprofloxacin

 

 

 

 

1.  Carfilzomib

 

Carfilzomib is an anti-cancer drug. It is a peptide derivative that selectively inhibits the activity of the 20S proteasome. The MicroGram Carfilzomib Assay Kit is designed for measurement of micrograms of carfilzomib. 

The assay is based on increase of fluorescence at 535 nm of the assay reagent C33 in the presence of carfilzomib. The assay kit can be used for measurement of carfilzomib concentrations in drug discovery and development. Due to the insolubility of carfilzomib in water, measurement of carfilzomib concentration is performed in ethanol. The assay is not compatible with thiol compounds or metal chelators such EDTA.

 

 

 

 

 

 

 

 

 

MicroGram Carfilzomib Assay Kit (Catalog No CFZ200) 

Includes 1 ml of 10 x C33 dye for 200 assays using 96-well plates. Cuvettes may also be used for the assay.

 

 

 

 

 

 

 

2.  Cisplatin

 

Cisplatin [or cis-diamminedichloroplatinum, Pt(NH3)2Cl2] is the first member of platinumcontaining anti-cancer drugs. It binds DNA and causes DNA crosslinking which ultimately triggers apoptosis (programmed cell death). The MicroMolar Cisplatin Assay Kit (Catalog No CPT200) is designed for throughput measurement of micromolar concentrations of Cisplatin. 

The assay is based on the light absorbance at 535 nm. The assay kit can be used for assays of cisplatin in drug discovery, drug development, pharmaceutical samples and biological samples.

 

 

 

 

 

 

 

MicroMolar Cisplatin Assay Kit (Catalog No CPT200) 

Includes 4 ml of Reagent A, 0.080 ml of 50 x Reagent B, and 2 ml of 10 x Reagent C. It is for 200 assays using 96-well plates. Cuvettes may also be used for measurements.