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TUNR Flexible Gene Editing for Endogenous Genes
제품명: TUNR Flexible Gene Editing for Endogenous Genes
용도:
메이커: Canopy Biosciences
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소개

 

TUNR Flexible Gene Editing for Endogenous Genes

  

The TUNR Flexible Gene Editing System for Endogenous Genes allows you to generate four cell lines or animal models with four different levels of knockdown of your endogenous gene of interest.

 

   

사진.PNGThe TUNR Flexible Gene Editing system allows for the modulation of expression of virtually any endogenous gene. The system leverages CRISPR-Cas9 genome editing technology to integrate TUNR sequences of varying strengths at a precise location within your gene of interest.   

 

•   Precisely tune gene expression from 100% all the way down to complete

    knockout 

•   Model ranges of gene expression reflecting diversity in patient populations  

•   Control endogenous gene expression–eliminate artifacts from ectopic expression  

•   Knockdown essential genes where knockout would result in lethality


 

 

 

How the TUNR Flexible Gene Editing System works 

 

 

Introduction of the TUNR polyA track results in reduced gene expression.The TUNR Flexible Gene Editing System leverages the CRISPR-Cas9 system for targeted integration of a polyA track at a preciselocation within the targeted gene.


License 

Canopy Biosciences holds the exclusive license for TUNR from Washington University and Johns Hopkins University. 


 


WUSTL logoJohns Hopkins logo

 

  

주문정보

TUNR0008          TUNR Endogenous Gene Kits          1 kit

Add-ons            CRISPR validation                       Option

 

 

The kit contains everything you need to alter the expression of your gene, including:

•  crNA designed to specifically target the precise location to integrate the TUNR sequences in your gene of interest •  tracRNA

•  Cas9 protein 

•  Oligonucleotides, containing one of four TUNR sequences flanked by homology arms to your gene of interest 

  -   TUNR-L Lower level of repression  

  -   TUNR-ML Lower level of repression  

  -   TUNR-MH Higher level of repression  

  -   TUNR-H Higher level of repression  

•  Forward and Reverse Primers


Required Information 

1.  Species (Ex: Human, Mouse, Rat, Other)

2.  Gene ID 

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