[Biolog 웨비나] 크론병 장간막 지방(Creeping Fat) 마이크로바이옴의 유래
|Date : 2020.12.09|
크론병 장간막 지방 마이크로바이옴의 유래
(Microbiome Origins of Creeping Fat in Crohn’s Disease)
• Presented by : Dr. Connie W. H. Ha, PhD
F. Widjaja Foundation
Inflammatory Bowel and Immunobiology Research Institute
Cedars-Sinai Medical Center, Los Angeles, CA
• Presented Live : Oct 29, 2020
Webinar Topics Include
• In many Crohn’s disease patients, their mesenteric fat tissue has a peculiar creeping activity and it specifically wraps around
the site of intestinal inflammation.
• Gut bacteria can translocate to the fat and remain viable, but the bacterial profile of creeping fat is distinct from healthy
fat tissue and from ulcerative colitis, the other form of inflammatory bowel disease.
• Anaerobic Clostridium innocuum seems to thrive in creeping fat and the clinical isolates of this species was studied using
Biolog AN MicroPlates™, providing interesting insights into their metabolic capabilities.
• Creeping migration of the fat is initially a protective mechanism to prevent the gut bacteria from getting into the
bloodstream, but ends up making the disease worse.