Biolog Metabolic Assay 로 암과 싸우는 T 세포의 이노신(inosine) 대사 활성 발견  

(Metabolic Reprogramming of T Cells to Promote Anti-tumor Immunity)

• Presented by:   Dr. JN Rashida Gnanaprakasam, Center for Childhood Cancer and Blood Diseases, 

                     Abigail Wexner Research Institute, Nationwide Children’s Hospital Ohio State University

• Presented Live:  August 20, 2020 

Webinar Topics Include

•  Discovery of an inosine metabolic pathway that provides for the nutritional needs of T cells following activation under

   glucose restriction

•  The essential role of inosine and purine nucleoside phosphorylase (PNP) in survival of T cells versus cancer cells

•  Demonstration that inosine treated T cells can extend life of mice with implanted tumors that are defective in

   metabolizing inosine

•  Potential of inosine to enhance cancer immunotherapy by improving metabolic fitness of T cells and overcoming

   immunosuppressive barriers in the tumor microenvironment

                         Metabolic Reprogramming of T Cells to Promote Anti-tumor Immunity from Biolog on Vimeo.