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[항생제 내성] 항생제 내성과 새로운 세균성 약물 유출 펌프 탐색 (Antibiotic Resistance and the Hunt for Novel Bacterial Drug Efflux Pumps)
인성크로마텍(주)
Date : 2022.04.14

 

항생제 내성과 새로운 세균성 약물 유출 펌프 탐색

Antibiotic Resistance and the Hunt for Novel Bacterial Drug Efflux Pumps

 


•  Presented by :  Dr. Ian Paulsen, Director, ARC Centre of Excellence in Synthetic Biology, 

                      Macquarie University Sydney NSW Australia               

•  Presented Live : December 09, 2021


 

Webinar Topics Include

 

•  Transcription and TraDIS were used to identify membrane proteins of unknown function that might potentially be new 

   multidrug efflux pumps

•  Candidate genes were cloned and expressed in E. coli and Biolog Phenotype MircoArrays™ 11-20 were used to identify

   putative substrates

•  Transport assays were used and we discovered three putative novel drug efflux pump families

•  Biochemical and biophysical assays of the purified proteins confirmed their interaction with substrates



 

Antibiotic Resistance and the Hunt for Novel Bacterial Drug Efflux Pumps from Biolog on Vimeo.