인성크로마텍 로고

검색버튼
퀵메뉴 펼침

o
p
e
n
c
l
o
s
e

Libraries

라이브러리


응용노트

제품 어플리케이션 자료가 정리되어 있습니다.
  • 홈으로home
  • > 라이브러리 >
  • 응용노트
[점도] Drug Injectability and Viscosity
인성크로마텍(주)
Date : 2020.02.11
첨부자료가 존재합니다. 자료는 회원만 열람이 가능합니다.(로그인 하신 후 이용하세요)
분류 : Analytical Products > RheoSense

 

Drug Injectability and Viscosity


 

In protein therapeutics, major resources are dedicated toward the development of self-injection formulations for:

 

▶ Sustainable Release

▶ Subcutaneous Injection

 

When sustainable release and subcutaneous injection are achieved, the concentration of protein inevitably increases, causing an 

increase in viscosity. The increase in viscosity creates significant challenges in Injectability, since high viscosity requires high 

injection force. This, in turn, affects how an auto-injection system needs to be designed to achieve optimum performance. 

 

 

INJECTABILITY AND VISCOSITY AT HIGH SHEAR RATES


A drug injected through a small needle (e.g. 27 gauge needle), with a rate for the injection time of 10 seconds, will have a shear 

rate inside of the needle which is estimated to be 160,000 s-1.It is important to note that at this specific shear rate, the viscosity 

of the drug can be significantly different from which it would be at a lower shear rate. 

 


Viscosity_v._Shear_rate.png

 


The viscosity of a model drug at a shear rate of 100,000 1/s is half of the viscosity at a shear rate of 10,000 1/s as shown in the 

graph. Therefore, in order to estimate accurate injection force, the viscosity should be measured at the shear rate inside of the 

needle.


Accurate viscosity measurements and accurate injection force can be estimated with m-VROC™ viscometer since viscosity values 

at shear rates of up to 90,000~200,000 s-1 , taking place inside of the needle, can be measured with high accuracy. 

 

 

Piston_Friction_Image.png

 

 

Taking the Guesswork Out of Injectability Studies with RheoSense Viscometers


m-VROC™ allows viscosity measurements up to 200,000 s-1 and eliminates the guesswork out of injectability studies in early

stage formulation development by allowing direct and accurate estimation of the injection force.

 

The table below shows how the injection force, estimated with the measured viscosities at the shear rate inside of the needle, 

corroborates well with the accumulated data. 

 

 

Injectability.png

(Diameter of the plunger is 6.35 mm for the estimation and the needle length is ½ inch.) 

 


The difference between the estimated injection force and the reported injection force is typically due to the gliding force of the 

piston against the barrel, which fluctuates from syringe to syringe and from one model to another.

 


* 보다 자세한 내용은 첨부 파일을 통해 확인 가능 합니다 *